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NPHS1 / Nephrin Antibody (aa1218-1234)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O60500 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 135kDa |
| Dilution | ELISA (1:1000), IHC-P (20 µg/ml), |
| Gene ID | 4868 |
|---|---|
| Other Names | Nephrin, Renal glomerulus-specific cell adhesion receptor, NPHS1, NPHN |
| Target/Specificity | Amino acids 1218 to 1234 of human NPHS1 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | NPHS1 / Nephrin Antibody (aa1218-1234) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NPHS1 |
|---|---|
| Synonyms | NPHN |
| Function | Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane. |
| Tissue Location | Specifically expressed in podocytes of kidney glomeruli |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).
References
Kestilae M.,et al.Mol. Cell 1:575-582(1998).
Tikhomirov E.,et al.Hum. Genet. 125:334-334(2009).
Grunkemeyer J.A.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Holthoefer H.,et al.Am. J. Pathol. 155:1681-1687(1999).
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