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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   NRG3 Antibody   

NRG3 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - NRG3 Antibody ALS11251
    Anti-NRG3 antibody IHC of human adrenal medulla.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P56975
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 78kDa
Dilution ELISA (1:1000), IHC-P (20 µg/ml),
Additional Information
Gene ID 10718
Other Names Pro-neuregulin-3, membrane-bound isoform, Pro-NRG3, Neuregulin-3, NRG-3, NRG3
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsNRG3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NRG3
Function Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Cellular Location Pro-neuregulin-3, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form
Tissue Location Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes
Research Areas
Citations (0)

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Background

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

References

Zhang D.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:9562-9567(1997).
Carteron C.,et al.J. Cell Sci. 119:898-909(2006).
Tiao J.Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Sweeney C.,et al.J. Biol. Chem. 275:19803-19807(2000).

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$ 395.00
Cat# ALS11251
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