|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (20 µg/ml), WB (1-3 µg/ml),|
|Other Names||Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8|
|Target/Specificity||A synthetic peptide within amino acid residues 1-50 of human RGS2 was used as immunogen.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||RGS2 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).|
|Cellular Location||Isoform 1: Cell membrane. Cytoplasm Nucleus, nucleolus Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus|
|Tissue Location||Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL)|
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Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Siderovski D.P.,et al.DNA Cell Biol. 13:125-147(1994).
Heximer S.P.,et al.J. Biol. Chem. 276:14195-14203(2001).
Gu S.,et al.Mol. Pharmacol. 73:1-11(2008).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Kim J.W.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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