|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (20 µg/ml), WB (1-3 µg/ml),|
|Other Names||Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8|
|Target/Specificity||A synthetic peptide within amino acid residues 1-50 of human RGS2 was used as immunogen.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||RGS2 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).|
|Cellular Location||Isoform 1: Cell membrane Cytoplasm. Nucleus, nucleolus Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus|
|Tissue Location||Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Siderovski D.P.,et al.DNA Cell Biol. 13:125-147(1994).
Heximer S.P.,et al.J. Biol. Chem. 276:14195-14203(2001).
Gu S.,et al.Mol. Pharmacol. 73:1-11(2008).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Kim J.W.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.