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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RGS2 Antibody (aa1-50)   

RGS2 Antibody (aa1-50)

Rabbit Polyclonal Antibody

     
  • IHC - RGS2 Antibody (aa1-50) ALS11256
    Anti-RGS2 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P41220
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Dilution IHC-P (20 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 5997
Other Names Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8
Target/Specificity A synthetic peptide within amino acid residues 1-50 of human RGS2 was used as immunogen.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsRGS2 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS2
Synonyms G0S8
Function Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
Cellular Location Isoform 1: Cell membrane Cytoplasm. Nucleus, nucleolus Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus
Tissue Location Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL)
Research Areas
Citations (0)

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Background

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

References

Siderovski D.P.,et al.DNA Cell Biol. 13:125-147(1994).
Heximer S.P.,et al.J. Biol. Chem. 276:14195-14203(2001).
Gu S.,et al.Mol. Pharmacol. 73:1-11(2008).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Kim J.W.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11256
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