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RGS2 Antibody (aa1-50)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P41220 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24kDa |
| Dilution | IHC-P (20 µg/ml), WB (1-3 µg/ml), |
| Gene ID | 5997 |
|---|---|
| Other Names | Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8 |
| Target/Specificity | A synthetic peptide within amino acid residues 1-50 of human RGS2 was used as immunogen. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | RGS2 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RGS2 |
|---|---|
| Synonyms | G0S8 |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320). |
| Cellular Location | [Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus [Isoform 3]: Cell membrane. Cytoplasm Nucleus, nucleolus |
| Tissue Location | Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
References
Siderovski D.P.,et al.DNA Cell Biol. 13:125-147(1994).
Heximer S.P.,et al.J. Biol. Chem. 276:14195-14203(2001).
Gu S.,et al.Mol. Pharmacol. 73:1-11(2008).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Kim J.W.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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