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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   GLUP / PACRG Antibody (aa204-215)   

GLUP / PACRG Antibody (aa204-215)

Rabbit Polyclonal Antibody

     
  • IHC - GLUP / PACRG Antibody (aa204-215) ALS11257
    Anti-PACRG antibody IHC of human colon.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96M98
Reactivity Human, Mouse, Chicken
Host Rabbit
Clonality Polyclonal
Calculated MW 33kDa
Dilution ELISA (1:2000-1:10000), IHC-P (2.5 µg/ml), WB (1:500-1:3000)
Additional Information
Gene ID 135138
Other Names Parkin coregulated gene protein, Molecular chaperone/chaperonin-binding protein, PARK2 coregulated gene protein, PACRG, GLUP
Target/Specificity Amino acids 204-215 of Human PACRG protein.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsGLUP / PACRG Antibody (aa204-215) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PACRG
Synonyms GLUP
Function Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.
Tissue Location Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas Expressed in primary Schwann cells and very weakly by monocyte- derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.
Research Areas
Citations (0)

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Background

Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.

References

West A.B.,et al.J. Mol. Biol. 326:11-19(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Imai Y.,et al.J. Biol. Chem. 278:51901-51910(2003).

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$ 395.00
Cat# ALS11257
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