CBX4 Antibody (aa95-107)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | O00257 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 61kDa |
Dilution | ELISA (1:10000-1:40000), IF (1:100-1:400), IHC-P (2.5 µg/ml), WB (1:1000-1:4000) , |
Gene ID | 8535 |
---|---|
Other Names | E3 SUMO-protein ligase CBX4, 6.3.2.-, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4 |
Target/Specificity | aa 95-107 of Human PC2 protein. |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | CBX4 Antibody (aa95-107) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CBX4 |
---|---|
Function | E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). |
Cellular Location | Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235) |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
References
Satijn D.P.E.,et al.Mol. Cell. Biol. 17:6076-6086(1997).
Salichs E.,et al.PLoS Genet. 5:E1000397-E1000397(2009).
Liu M.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Satijn D.P.E.,et al.Mol. Cell. Biol. 17:4105-4113(1997).
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