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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KALRN / KALIRIN Antibody (aa1591-1605)   

KALRN / KALIRIN Antibody (aa1591-1605)

Rabbit Polyclonal Antibody

     
  • IHC - KALRN / KALIRIN Antibody (aa1591-1605) ALS11265
    Anti-KALRN antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O60229
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 340kDa
Dilution ELISA (1:1000), IHC-P (5 µg/ml),
Additional Information
Gene ID 8997
Other Names Kalirin, 2.7.11.1, Huntingtin-associated protein-interacting protein, Protein Duo, Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, KALRN, DUET, DUO, HAPIP, TRAD
Target/Specificity A synthetic peptide corresponding to amino acids 1591-1605 (KEP LQL PKT PAK QRN) of human HAPIP/KALRN protein.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsKALRN / KALIRIN Antibody (aa1591-1605) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KALRN (HGNC:4814)
Function Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton Note=Associated with the cytoskeleton
Tissue Location Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
Research Areas
Citations (0)

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Background

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.

References

Colomer V.,et al.Hum. Mol. Genet. 6:1519-1525(1997).
Kawai T.,et al.Gene 227:249-255(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11265
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