|Application ||IHC-P, E|
|Dilution||ELISA (1:1000), IHC-P (5 µg/ml),|
|Other Names||Kalirin, 220.127.116.11, Huntingtin-associated protein-interacting protein, Protein Duo, Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, KALRN, DUET, DUO, HAPIP, TRAD|
|Target/Specificity||A synthetic peptide corresponding to amino acids 1591-1605 (KEP LQL PKT PAK QRN) of human HAPIP/KALRN protein.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KALRN / KALIRIN Antibody (aa1591-1605) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton Note=Associated with the cytoskeleton|
|Tissue Location||Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.|
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Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
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Kawai T.,et al.Gene 227:249-255(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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