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TRPC3 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | Q13507 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 96kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 7222 |
|---|---|
| Other Names | Short transient receptor potential channel 3, TrpC3, Transient receptor protein 3, TRP-3, hTrp-3, hTrp3, TRPC3, TRP3 |
| Target/Specificity | 14 amino acid peptide from near the carboxy terminus of human TRPC3 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | TRPC3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRPC3 |
|---|---|
| Synonyms | TRP3 |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:8646775, PubMed:9417057, PubMed:9930701, PubMed:20095964, PubMed:30139744, PubMed:29726814, PubMed:35051376). May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors (PubMed:8646775). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
References
Zhu X.,et al.Cell 85:661-671(1996).
Xu X.-Z.S.,et al.Cell 89:1155-1164(1997).
Yildirim E.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:3307-3311(2005).
Yamazaki D.,et al.Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
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