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DKK1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - DKK1 Antibody (C-Terminus) ALS11283
    Anti-DKK1 antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O94907
Reactivity Human, Mouse, Monkey, Pig, Goat, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 29kDa
Dilution ELISA (1:128000), IHC-P (10 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 22943
Other Names Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1
Target/Specificity Human DKK1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDKK1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DKK1
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Cellular Location Secreted.
Tissue Location Placenta.
Research Areas
Citations (0)

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Background

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

References

Fedi P.,et al.J. Biol. Chem. 274:19465-19472(1999).
Krupnik V.E.,et al.Gene 238:301-313(1999).
Tate G.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Roessler E.,et al.Cytogenet. Cell Genet. 89:220-224(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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$ 395.00
Cat# ALS11283
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