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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BMP10 Antibody (aa22-35)   

BMP10 Antibody (aa22-35)

Rabbit Polyclonal Antibody

     
  • IHC - BMP10 Antibody (aa22-35) ALS11286
    Anti-BMP10 antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O95393
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Dilution ELISA (1:1000), IHC-P (20 µg/ml),
Additional Information
Gene ID 27302
Other Names Bone morphogenetic protein 10, BMP-10, BMP10
Target/Specificity Amino acids 22 to 35 of human BMP10
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsBMP10 Antibody (aa22-35) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMP10
Function Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Cellular Location Secreted.
Tissue Location Detected in mammary epithelia (at protein level).
Research Areas
Citations (0)

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Background

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

References

Celeste A.J.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mazerbourg S.,et al.J. Biol. Chem. 280:32122-32132(2005).
David L.,et al.Blood 109:1953-1961(2007).
Ye L.,et al.Cancer Sci. 101:2137-2144(2010).

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$ 395.00
Cat# ALS11286
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