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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CTNS / Cystinosin Antibody (aa268-285)   

CTNS / Cystinosin Antibody (aa268-285)

Rabbit Polyclonal Antibody

     
  • IHC - CTNS / Cystinosin Antibody (aa268-285) ALS11288
    Anti-CTNS antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O60931
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 42kDa
Dilution ELISA (1:1000), IHC-P (1.25 µg/ml),
Additional Information
Gene ID 1497
Other Names Cystinosin, CTNS
Target/Specificity Amino acids 268 to 285 of human CTNS.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsCTNS / Cystinosin Antibody (aa268-285) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTNS
Function Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.
Cellular Location Isoform 1: Lysosome membrane; Multi-pass membrane protein. Melanosome
Tissue Location Strongly expressed in pancreas, kidney (adult and fetal), skeletal muscle, melanocytes and keratinocytes Expressed at lower levels in placenta and heart. Weakly expressed in lung, liver and brain (adult and fetal). Isoform 2 represents 5-20 % of CTNS transcripts, with the exception of the testis that expresses both isoforms in equal proportions
Research Areas
Citations (0)

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Background

Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.

References

Town M.,et al.Nat. Genet. 18:319-324(1998).
Touchman J.W.,et al.Genome Res. 10:165-173(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11288
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