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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CASP8AP2 / FLASH Antibody (C-Terminus)   

CASP8AP2 / FLASH Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - CASP8AP2 / FLASH Antibody (C-Terminus) ALS11289
    Immunocytochemistry of FLASH in HeLa cells with FLASH antibody at 10 ug/ml.
  • IF - CASP8AP2 / FLASH Antibody (C-Terminus) ALS11289
    Immunofluorescence of FLASH in HeLa cells with FLASH antibody at 10 ug/ml.
  • WB - CASP8AP2 / FLASH Antibody (C-Terminus) ALS11289
    Western blot of FLASH in HeLa whole cell lysate with FLASH antibody at 0.5 ug/ml.
  • IHC - CASP8AP2 / FLASH Antibody (C-Terminus) ALS11289
    Anti-CASP8AP2 / FLASH antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q9UKL3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 223kDa
Dilution IHC-P (10 µg/ml), WB (0.25-0.5 µg/ml),
Additional Information
Gene ID 9994
Other Names CASP8-associated protein 2, FLICE-associated huge protein, CASP8AP2 (HGNC:1510)
Target/Specificity synthetic peptide corresponding to amino acids near the carboxy-terminus of human FLASH which differ from those of mouse by one amino acid
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCASP8AP2 / FLASH Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP8AP2 (HGNC:1510)
Function Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Cellular Location Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation
Research Areas
Citations (0)

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Background

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.

References

Kimura T.,et al.Nature 401:662-663(1999).
Yan M.D.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 7:65-73(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 395.00
Cat# ALS11289
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