CASP8AP2 / FLASH Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, ICC |
---|---|
Primary Accession | Q9UKL3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 223kDa |
Dilution | IHC-P (10 µg/ml), WB (0.25-0.5 µg/ml), |
Gene ID | 9994 |
---|---|
Other Names | CASP8-associated protein 2, FLICE-associated huge protein, CASP8AP2 (HGNC:1510) |
Target/Specificity | synthetic peptide corresponding to amino acids near the carboxy-terminus of human FLASH which differ from those of mouse by one amino acid |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | CASP8AP2 / FLASH Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CASP8AP2 (HGNC:1510) |
---|---|
Function | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. |
Cellular Location | Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation |
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Background
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
References
Kimura T.,et al.Nature 401:662-663(1999).
Yan M.D.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 7:65-73(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Mungall A.J.,et al.Nature 425:805-811(2003).
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