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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   CENPU / MLF1IP Antibody (phospho-Thr78)   

CENPU / MLF1IP Antibody (phospho-Thr78)

Rabbit Polyclonal Antibody

     
  • IHC - CENPU / MLF1IP Antibody (phospho-Thr78) ALS11294
    Anti-MLF1IP / PBIP1 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession Q71F23
Reactivity Human, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Dilution ELISA (1:5000-1:25000), IHC-P (10 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 79682
Other Names Centromere protein U, CENP-U, Centromere protein of 50 kDa, CENP-50, Interphase centromere complex protein 24, KSHV latent nuclear antigen-interacting protein 1, MLF1-interacting protein, Polo-box-interacting protein 1, CENPU, ICEN24, KLIP1, MLF1IP, PBIP1
Target/Specificity Amino acids surrounding Thr78 of human MLF1IP protein.
Reconstitution & Storage Store vial at -20 C prior to opening. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 C or below. Avoid cycles of freezing and thawing.
PrecautionsCENPU / MLF1IP Antibody (phospho-Thr78) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CENPU
Synonyms ICEN24, KLIP1, MLF1IP, PBIP1
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.
Cellular Location Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates
Tissue Location Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells Expressed at high levels in glioblastoma cell lines
Volume 100 µl
Research Areas
Citations (0)

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Background

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

References

Pan H.-Y.,et al.J. Virol. 77:9758-9768(2003).
Hanissian S.H.,et al.Oncogene 23:3700-3707(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Hanissian S.H.,et al.Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11294
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