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ALB / Serum Albumin Antibody (Biotin)

Rabbit Polyclonal Antibody

     
  • IHC - ALB / Serum Albumin Antibody (Biotin) ALS11297
    Anti-Serum Albumin antibody IHC of human liver.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P02768
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 69kDa
Dilution ELISA (1:5000-1:25000), IHC-P (2.5 µg/ml), WB (1:1000-1:5000)
Additional Information
Gene ID 213
Other Names Serum albumin, ALB
Target/Specificity Human Serum Albumin.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsALB / Serum Albumin Antibody (Biotin) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALB
Function Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017).
Cellular Location Secreted.
Tissue Location Plasma.
Volume 50 µl
Research Areas
Citations (0)
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Background

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

References

Lawn R.M.,et al.Nucleic Acids Res. 9:6103-6114(1981).
Dugaiczyk A.,et al.Proc. Natl. Acad. Sci. U.S.A. 79:71-75(1982).
Minghetti P.P.,et al.J. Biol. Chem. 261:6747-6757(1986).
Yang S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Huang M.C.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS11297
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