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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   APC6 / CDC16 Antibody (phospho-Thr580)   

APC6 / CDC16 Antibody (phospho-Thr580)

Rabbit Polyclonal Antibody

     
  • IHC - APC6 / CDC16 Antibody (phospho-Thr580) ALS11305
    Anti-CDC16 / Apc6 antibody IHC of human lung, respiratory epithelium.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q13042
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 72kDa
Dilution ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:3000)
Additional Information
Gene ID 8881
Other Names Cell division cycle protein 16 homolog, Anaphase-promoting complex subunit 6, APC6, CDC16 homolog, CDC16Hs, Cyclosome subunit 6, CDC16, ANAPC6
Target/Specificity Amino acids 575-588 of Human Apc6 protein.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAPC6 / CDC16 Antibody (phospho-Thr580) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC16
Synonyms ANAPC6
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle
Research Areas
Citations (0)

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Background

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

References

Tugendreich S.,et al.Cell 81:261-268(1995).
Zhou P.K.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ollendorff V.,et al.J. Biol. Chem. 272:32011-32018(1997).

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$ 395.00
Cat# ALS11305
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