AP1G1 / Adaptin Gamma 1 Antibody (aa646-659)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | O43747 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 91kDa |
Dilution | ELISA (1:2000-1:8000), IHC-P (2.5 µg/ml), WB (1:500-1:2000) |
Gene ID | 164 |
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Other Names | AP-1 complex subunit gamma-1, Adaptor protein complex AP-1 subunit gamma-1, Adaptor-related protein complex 1 subunit gamma-1, Clathrin assembly protein complex 1 gamma-1 large chain, Gamma1-adaptin, Golgi adaptor HA1/AP1 adaptin subunit gamma-1, AP1G1, ADTG, CLAPG1 |
Target/Specificity | aa 646-659 of Human AP1G1. |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | AP1G1 / Adaptin Gamma 1 Antibody (aa646-659) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AP1G1 |
---|---|
Synonyms | ADTG, CLAPG1 |
Function | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). |
Cellular Location | Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (PubMed:12773381). Co-localizes with AFTPH/aftiphilin in the cytoplasm (PubMed:15758025). |
Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
References
Peyrard M.,et al.Genomics 50:275-280(1998).
Takatsu H.,et al.J. Biol. Chem. 273:24693-24700(1998).
Martin J.,et al.Nature 432:988-994(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Deneka M.,et al.EMBO J. 22:2645-2657(2003).
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