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AP3D1 / Adaptin Delta Antibody (aa686-698)

Goat Polyclonal Antibody

     
  • WB - AP3D1 / Adaptin Delta Antibody (aa686-698) ALS11309
    Anti-AP3D1 Antibody - Western Blot.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O14617
Reactivity Human, Chicken
Host Goat
Clonality Polyclonal
Calculated MW 130kDa
Dilution ELISA (1:5000-1:20000), IHC-P (2.5 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 8943
Other Names AP-3 complex subunit delta-1, AP-3 complex subunit delta, Adaptor-related protein complex 3 subunit delta-1, Delta-adaptin, AP3D1
Target/Specificity aa 686-698 of Human AP3D1.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsAP3D1 / Adaptin Delta Antibody (aa686-698) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AP3D1
Function Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
Cellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis
Research Areas
Citations (0)

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Background

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

References

Ooi C.E.,et al.EMBO J. 16:4508-4518(1997).
Simpson F.,et al.J. Cell Biol. 137:835-845(1997).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Zhang C.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11309
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