|Application ||WB, IHC-P, IF, ICC, E|
|Calculated MW||36949 Da|
|Dilution||ELISA (1:5000-1:30000), IHC-P (2.5 µg/ml), WB (1:500-1:3000)|
|Other Names||Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51|
|Target/Specificity||Amino acids 252-264 of human Bmi1 protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||BMI1 / PCGF4 Antibody (aa252-264) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.|
|Cellular Location||Nucleus. Cytoplasm.|
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