|Application ||WB, IHC-P, E, IP|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:1000-1:5000), IHC-P (1:500), WB (1:500-1:2000)|
|Other Names||Cyclin-T1, CycT1, Cyclin-T, CCNT1|
|Target/Specificity||Cyclin T1 peptide corresponding to an internal region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||CCNT1 / Cyclin T1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.
Wei P.,et al.Cell 92:451-462(1998).
Peng J.-M.,et al.Genes Dev. 12:755-762(1998).
Wu X.,et al.Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
Parada C.A.,et al.EMBO J. 18:3688-3701(1999).
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