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>   home   >   Products   >   Primary Antibodies   >   EIF3S5 / EIF3F Antibody (aa114-125)   

EIF3S5 / EIF3F Antibody (aa114-125)

Rabbit Polyclonal Antibody

     
  • WB - EIF3S5 / EIF3F Antibody (aa114-125) ALS11323
    Anti-eIF3F Antibody - Western Blot.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E, IP
Primary Accession O00303
Reactivity Human, Mouse, Rat, Chicken, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 38kDa
Dilution ELISA (1:10000-1:40000), IHC-P (2.5 µg/ml), WB (1:200-1:2000)
Additional Information
Gene ID 8665
Other Names Eukaryotic translation initiation factor 3 subunit F {ECO:0000255|HAMAP-Rule:MF_03005}, eIF3f {ECO:0000255|HAMAP-Rule:MF_03005}, Deubiquitinating enzyme eIF3f, 3.4.19.12, Eukaryotic translation initiation factor 3 subunit 5 {ECO:0000255|HAMAP-Rule:MF_03005}, eIF-3-epsilon {ECO:0000255|HAMAP-Rule:MF_03005}, eIF3 p47 {ECO:0000255|HAMAP-Rule:MF_03005}, EIF3F {ECO:0000255|HAMAP-Rule:MF_03005}
Target/Specificity Amino acids 114-125 of human eIF3f protein.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsEIF3S5 / EIF3F Antibody (aa114-125) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF3F {ECO:0000255|HAMAP-Rule:MF_03005}
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
Citations (0)

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Background

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

References

Asano K.,et al.J. Biol. Chem. 272:27042-27052(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Shi J.,et al.J. Biol. Chem. 278:5062-5071(2003).

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$ 395.00
Cat# ALS11323
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