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EMI2 / FBXO43 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q4G163 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 78kDa |
| Dilution | ELISA (1:10000-1:50000), IHC-P (2.5 µg/ml), WB (1:500-1:3000) |
| Gene ID | 286151 |
|---|---|
| Other Names | F-box only protein 43, Endogenous meiotic inhibitor 2, FBXO43, EMI2 |
| Target/Specificity | A region approximately 60 residues downstream of the amino terminal end of human Fbp5B protein. |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | EMI2 / FBXO43 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXO43 |
|---|---|
| Synonyms | EMI2 |
| Function | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. |
| Tissue Location | Expressed in the testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).
References
Nusbaum C.,et al.Nature 439:331-335(2006).
Jin J.,et al.Genes Dev. 18:2573-2580(2004).
Tung J.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:4318-4323(2005).
Hansen D.V.,et al.Proc. Natl. Acad. Sci. U.S.A. 103:608-613(2006).
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