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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FBX09 / FBXO9 Antibody (aa431-447)   

FBX09 / FBXO9 Antibody (aa431-447)

Rabbit Polyclonal Antibody

     
  • IHC - FBX09 / FBXO9 Antibody (aa431-447) ALS11326
    Anti-FBXO9 antibody IHC of human pancreas.
  • WB - FBX09 / FBXO9 Antibody (aa431-447) ALS11326
    Anti-FBOX9 Antibody - Western Blot.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9UK97
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 52kDa
Dilution ELISA (1:5000-1:25000), IHC-P (5 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 26268
Other Names F-box only protein 9, Cross-immune reaction antigen 1, Renal carcinoma antigen NY-REN-57, FBXO9, FBX9, VCIA1
Target/Specificity Amino acids 431-447 of human FBOX9 protein.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsFBX09 / FBXO9 Antibody (aa431-447) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO9
Synonyms FBX9, VCIA1
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

References

Winston J.T.,et al.Curr. Biol. 9:1180-1182(1999).
Deng H.-X.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11326
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