GGA2 Antibody (aa249-265)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | Q9UJY4 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 67kDa |
Dilution | IHC-P (2.5 µg/ml) |
Gene ID | 23062 |
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Other Names | ADP-ribosylation factor-binding protein GGA2, Gamma-adaptin-related protein 2, Golgi-localized, gamma ear-containing, ARF-binding protein 2, VHS domain and ear domain of gamma-adaptin, Vear, GGA2, KIAA1080 |
Target/Specificity | Amino acids 249-265 of Human GGA2. This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Go ... |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | GGA2 Antibody (aa249-265) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GGA2 |
---|---|
Synonyms | KIAA1080 |
Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans- Golgi network (PubMed:15615712). |
Cellular Location | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein |
Tissue Location | Ubiquitously expressed. |
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Background
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
References
Boman A.L.,et al.Mol. Biol. Cell 11:1241-1255(2000).
Hirst J.,et al.J. Cell Biol. 149:67-80(2000).
Poussu A.,et al.J. Biol. Chem. 275:7176-7183(2000).
Loftus B.J.,et al.Genomics 60:295-308(1999).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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