CD121b / IL1R2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E, IP |
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Primary Accession | P27930 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 45kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 7850 |
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Other Names | Interleukin-1 receptor type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b, Interleukin-1 receptor type 2, membrane form, mIL-1R2, mIL-1RII, Interleukin-1 receptor type 2, soluble form, sIL-1R2, sIL-1RII, IL1R2, IL1RB |
Target/Specificity | Recombinant human IL-1R type II. |
Reconstitution & Storage | Store vial at -20 C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20 C or below. Avoid cycles of freezing and thawing. |
Precautions | CD121b / IL1R2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IL1R2 |
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Synonyms | IL1RB |
Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
Cellular Location | [Isoform Short]: Secreted |
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Provided below are standard protocols that you may find useful for product applications.
Background
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
References
McMahan C.J.,et al.EMBO J. 10:2821-2832(1991).
Liu C.,et al.J. Biol. Chem. 271:20965-20972(1996).
Chou H.-H.,et al.Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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