|Application ||WB, IHC-P, IF, E|
|Dilution||ELISA (1:4000-1:14000), IHC-P (2.5 µg/ml), WB (1:500-1:3000)|
|Other Names||Inhibitor of growth protein 1, ING1|
|Target/Specificity||Aa 285-296 of Human p33 ING1 protein (Inhibitor of growth family, member 1). This sequence shows 100% homology to all splice variants for ING1.|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||ING1 Antibody (aa285-296) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.|
|Tissue Location||Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
Garkavtsev I.A.,et al.Nat. Genet. 14:415-420(1996).
Garkavtsev I.A.,et al.Nat. Genet. 23:373-373(1999).
Jaeger D.,et al.Cancer Res. 59:6197-6204(1999).
Baranova A.V.,et al.Mol. Biol. (Mosk.) 34:263-269(2000).
Gunduz M.,et al.Cancer Res. 60:3143-3146(2000).
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