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ING1 Antibody (aa285-296)

Goat Polyclonal Antibody

     
  • IHC - ING1 Antibody (aa285-296) ALS11338
    Anti-ING1 antibody IHC of human brain, cortex.
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  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9UK53
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 47kDa
Dilution ELISA (1:4000-1:14000), IHC-P (2.5 µg/ml), WB (1:500-1:3000)
Additional Information
Gene ID 3621
Other Names Inhibitor of growth protein 1, ING1
Target/Specificity Aa 285-296 of Human p33 ING1 protein (Inhibitor of growth family, member 1). This sequence shows 100% homology to all splice variants for ING1.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsING1 Antibody (aa285-296) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ING1
Function Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
Cellular Location Nucleus.
Tissue Location Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines
Research Areas
Citations (0)
citation

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Background

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

References

Garkavtsev I.A.,et al.Nat. Genet. 14:415-420(1996).
Garkavtsev I.A.,et al.Nat. Genet. 23:373-373(1999).
Jaeger D.,et al.Cancer Res. 59:6197-6204(1999).
Baranova A.V.,et al.Mol. Biol. (Mosk.) 34:263-269(2000).
Gunduz M.,et al.Cancer Res. 60:3143-3146(2000).

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Discontinued
Cat# ALS11338
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