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TG / Thyroglobulin Antibody (clone 2H11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IHC-Fr |
|---|---|
| Primary Accession | P01266 |
| Reactivity | Human, Mouse, Rat, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2H11 |
| Calculated MW | 305kDa |
| Dilution | IHC-Fr (1:50-1:200), IHC-P (5 µg/ml), WB (1:400) |
| Gene ID | 7038 |
|---|---|
| Other Names | Thyroglobulin, Tg, TG |
| Target/Specificity | Human thyroglobulin protein. Hybridoma: Produced by the fusion between BALB/c mouse splenocytes and mouse myeloma SP2/0 cells after immunization with thyroglobulin from human thyroid gland using conventional hybridoma technology. |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | TG / Thyroglobulin Antibody (clone 2H11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TG (HGNC:11764) |
|---|---|
| Function | Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030). |
| Cellular Location | Secreted. Note=Secreted into the thyroid follicle lumen (PubMed:19509106). Localizes to colloid globules, a structure formed in the thyroid follicle lumen consisting of cross-linked TG arranged in concentric layers (PubMed:8626858, PubMed:11082042). |
| Tissue Location | Specifically expressed in the thyroid gland. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
References
Malthiery Y.,et al.Eur. J. Biochem. 165:491-498(1987).
van de Graaf S.A.R.,et al.Eur. J. Endocrinol. 136:508-515(1997).
Nusbaum C.,et al.Nature 439:331-335(2006).
Malthiery Y.,et al.Eur. J. Biochem. 147:53-58(1985).
Parma J.,et al.J. Mol. Biol. 196:769-779(1987).
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