|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Monkey|
|Dilution||ELISA (1:10000-1:40000), IHC-P (2.5 µg/ml), WB (1:500-1:2000)|
|Other Names||ATPase WRNIP1, 22.214.171.124, Werner helicase-interacting protein 1, WRNIP1 (HGNC:20876)|
|Target/Specificity||An internal region of the WHIP1 protein. The immunogen sequence shows 100% homology to human WHIP1 (isoform 1) and WHIP2 (isoform 2) with predicted molecular weights of 72.2 kD and 69.5 kD, respectively. The immunogen sequence also shows 100% homolog ...|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||WRNIP1 / WHIP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased.|
|Cellular Location||Nucleus. Note=Colocalizes with WRN in granular structures in the nucleus.|
|Tissue Location||Ubiquitously expressed.|
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Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
Kawabe Y.,et al.J. Biol. Chem. 276:20364-20369(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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