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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   AATF Antibody (C-Terminus)   

AATF Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - AATF Antibody (C-Terminus) ALS11370
    Immunofluorescence of AATF in Human Small Intestine cells with AATF antibody at 20 ug/ml.
  • IHC - AATF Antibody (C-Terminus) ALS11370
    Anti-AATF antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q9NY61
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 63kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 26574
Other Names Protein AATF, Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, AATF, CHE1, DED
Target/Specificity 12 amino acid peptide from near the carboxy terminus of human AATF
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsAATF Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AATF
Synonyms CHE1, DED
Function May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Cellular Location Nucleus, nucleolus
Tissue Location Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus
Research Areas
Citations (0)

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Background

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

References

Lindfors K.,et al.Biochem. Biophys. Res. Commun. 276:660-666(2000).
Fanciulli M.,et al.FASEB J. 14:904-912(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11370
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