|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (2.5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Angiotensin-converting enzyme 2, 18.104.22.168, ACE-related carboxypeptidase, Angiotensin-converting enzyme homolog, ACEH, Metalloprotease MPROT15, Processed angiotensin-converting enzyme 2, ACE2|
|Target/Specificity||synthetic peptide corresponding to amino acids near the center of human ACE2|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||ACE2 / ACE-2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function.|
|Cellular Location||Processed angiotensin-converting enzyme 2: Secreted|
|Tissue Location||Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level) Expressed in heart, kidney, testis, and gastrointestinal system|
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Provided below are standard protocols that you may find useful for product applications.
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Donoghue M.,et al.Circ. Res. 87:E1-E9(2000).
Tipnis S.R.,et al.J. Biol. Chem. 275:33238-33243(2000).
Douglas G.C.,et al.Endocrinology 145:4703-4711(2004).
Itoyama S.,et al.Am. J. Med. Genet. A 136:52-57(2005).
Suzuki Y.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
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