|Application ||WB, IHC-P, IF, ICC|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (2.5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5|
|Target/Specificity||16 amino acid peptide from near the carboxy terminus of human AES|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||AES / Groucho Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.|
|Tissue Location||Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver|
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Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
Scala L.A.,et al.Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
Hou E.W.,et al.DNA Cell Biol. 17:911-913(1998).
Liu Y.,et al.Zhonghua Wei Sheng Wu Xue He Mian Yi Xue Za Zhi 18:106-110(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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