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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   BANF1 / BAF / BCRP1 Antibody (C-Terminus)   

BANF1 / BAF / BCRP1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - BANF1 / BAF / BCRP1 Antibody (C-Terminus) ALS11379
    Western blot of BANF1 in mouse kidney tissue lysate with BANF1 antibody at (A) 0.5, (B) 1 and...
  • IHC - BANF1 / BAF / BCRP1 Antibody (C-Terminus) ALS11379
    Anti-BANF1 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O75531
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 10kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 8815
Other Names Barrier-to-autointegration factor, Breakpoint cluster region protein 1, Barrier-to-autointegration factor, N-terminally processed, BANF1, BAF, BCRG1
Target/Specificity 15 amino acid peptide from near the carboxy terminus of human BANF1.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsBANF1 / BAF / BCRP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BANF1
Synonyms BAF, BCRG1
Function Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self- destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.
Cellular Location Nucleus. Cytoplasm. Chromosome. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase May be included in HIV-1 virions via its interaction with viral GAG polyprotein. The phosphorylated form (by VRK1) shows a cytoplasmic localization
Tissue Location Widely expressed. Expressed in colon, brain, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen and testis. Not detected in thymus and peripheral blood leukocytes
Research Areas
Citations (0)

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Background

Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self- destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.

References

Lee M.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:1528-1533(1998).
Lynch R.A.,et al.Genomics 52:17-26(1998).
Zhang J.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Harris D.,et al.J. Biol. Chem. 275:39671-39677(2000).

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$ 395.00
Cat# ALS11379
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