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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   BIRC1 / NAIP Antibody (C-Terminus)   

BIRC1 / NAIP Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - BIRC1 / NAIP Antibody (C-Terminus) ALS11387
    Immunocytochemistry of NAIP in A549 cells with NAIP antibody at 10 ug/ml.
  • IF - BIRC1 / NAIP Antibody (C-Terminus) ALS11387
    Immunofluorescence of NAIP in A549 cells with NAIP antibody at 20 ug/ml.
  • WB - BIRC1 / NAIP Antibody (C-Terminus) ALS11387
    Western blot of NAIP in PC-3 cell lysate with NAIP antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
  • IHC - BIRC1 / NAIP Antibody (C-Terminus) ALS11387
    Anti-NAIP antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q13075
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 160kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 4671
Other Names Baculoviral IAP repeat-containing protein 1, Neuronal apoptosis inhibitory protein, NAIP, BIRC1
Target/Specificity synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsBIRC1 / NAIP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NAIP
Synonyms BIRC1
Function Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.
Tissue Location Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord
Research Areas
Citations (0)

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Background

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.

References

Roy N.,et al.Cell 80:167-178(1995).
Chen Q.,et al.Genomics 48:121-127(1998).
Schmutz J.,et al.Nature 431:268-274(2004).
Xu M.,et al.Biochim. Biophys. Acta 1574:35-50(2002).
van der Steege G.,et al.Eur. J. Hum. Genet. 3:87-95(1995).

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$ 395.00
Cat# ALS11387
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