|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Fructose-2, 6-bisphosphatase TIGAR, 220.127.116.11, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5|
|Target/Specificity||18 amino acid peptide from near the center of human TIGAR.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||TIGAR Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.|
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Provided below are standard protocols that you may find useful for product applications.
Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.
White K.E.,et al.Nat. Genet. 26:345-348(2000).
Cheng J.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bensaad K.,et al.Cell 126:107-120(2006).
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