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CARMA1 / CARD11 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | Q9BXL7 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 133kDa |
| Dilution | IHC-P (5 µg/ml), WB (0.5-2 µg/ml), |
| Gene ID | 84433 |
|---|---|
| Other Names | Caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1, Carma 1, CARD11, CARMA1 |
| Target/Specificity | synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | CARMA1 / CARD11 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CARD11 {ECO:0000303|PubMed:11278692, ECO:0000312|HGNC:HGNC:16393} |
|---|---|
| Function | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T- cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). |
| Cellular Location | Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. |
| Tissue Location | Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
References
Bertin J.,et al.J. Biol. Chem. 276:11877-11882(2001).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Gaide O.,et al.FEBS Lett. 496:121-127(2001).
Gaide O.,et al.FEBS Lett. 505:198-198(2001).
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