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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CARD8 / Cardinal / TUCAN Antibody (C-Terminus)   

CARD8 / Cardinal / TUCAN Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - CARD8 / Cardinal / TUCAN Antibody (C-Terminus) ALS11403
    Immunocytochemistry of CARD8 in K562 cells with CARD8 antibody at 10 ug/ml.
  • IF - CARD8 / Cardinal / TUCAN Antibody (C-Terminus) ALS11403
    Immunofluorescence of CARD8 in K562 cells with CARD8 antibody at 20 ug/ml.
  • IHC - CARD8 / Cardinal / TUCAN Antibody (C-Terminus) ALS11403
    Anti-CARD8 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q9Y2G2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 49kDa
Dilution IHC-P (5 µg/ml), WB (2 µg/ml),
Additional Information
Gene ID 22900
Other Names Caspase recruitment domain-containing protein 8, Apoptotic protein NDPP1, CARD-inhibitor of NF-kappa-B-activating ligand, CARDINAL, DACAR, Tumor up-regulated CARD-containing antagonist of CASP9, TUCAN, CARD8, KIAA0955, NDPP1
Target/Specificity synthetic peptide corresponding to amino acids at the C-terminus of human CARD8
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCARD8 / Cardinal / TUCAN Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CARD8
Synonyms KIAA0955, NDPP1
Function Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Cellular Location Cytoplasm. Nucleus
Tissue Location High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow
Research Areas
Citations (0)

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Background

Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

References

Nagase T.,et al.DNA Res. 6:63-70(1999).
Razmara M.,et al.J. Biol. Chem. 277:13952-13958(2002).
Zhang H.,et al.Int. J. Oncol. 20:1035-1040(2002).
Guiet C.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Bouchier-Hayes L.,et al.J. Biol. Chem. 276:44069-44077(2001).

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$ 395.00
Cat# ALS11403
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