|Application ||WB, IHC-P, IF, ICC|
|Dilution||IHC-P (5 µg/ml), WB (2 µg/ml),|
|Other Names||Caspase recruitment domain-containing protein 8, Apoptotic protein NDPP1, CARD-inhibitor of NF-kappa-B-activating ligand, CARDINAL, DACAR, Tumor up-regulated CARD-containing antagonist of CASP9, TUCAN, CARD8, KIAA0955, NDPP1|
|Target/Specificity||synthetic peptide corresponding to amino acids at the C-terminus of human CARD8|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||CARD8 / Cardinal / TUCAN Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow|
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Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Nagase T.,et al.DNA Res. 6:63-70(1999).
Razmara M.,et al.J. Biol. Chem. 277:13952-13958(2002).
Zhang H.,et al.Int. J. Oncol. 20:1035-1040(2002).
Guiet C.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Bouchier-Hayes L.,et al.J. Biol. Chem. 276:44069-44077(2001).
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