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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CARD9 Antibody (aa521-536)   

CARD9 Antibody (aa521-536)

Rabbit Polyclonal Antibody

     
  • ICC - CARD9 Antibody (aa521-536) ALS11404
    Immunocytochemistry of CARD9 in K562 cells with CARD9 antibody at 10 ug/ml.
  • WB - CARD9 Antibody (aa521-536) ALS11404
    Western blot of CARD9 expression in human MDA-MB-361 (A) and PC-3 (B) cell lysate with CARD9...
  • IHC - CARD9 Antibody (aa521-536) ALS11404
    Anti-CARD9 antibody IHC of human adrenal.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession Q9H257
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 62kDa
Dilution IHC-P (10 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 64170
Other Names Caspase recruitment domain-containing protein 9, hCARD9, CARD9
Target/Specificity Synthetic peptide (DRENTTGSDNTDTEGS) corresponding to amino acids 521 to 536 of human CARD9 The sequence is different from that of rat origin by two amino acids.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCARD9 Antibody (aa521-536) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CARD9
Function Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM- tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain
Research Areas
Citations (0)

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Background

Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM- tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.

References

Bertin J.,et al.J. Biol. Chem. 275:41082-41086(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Zahedi R.P.,et al.J. Proteome Res. 7:526-534(2008).

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$ 395.00
Cat# ALS11404
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