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CBLN1 / Cerebellin 1 Antibody

Rabbit Polyclonal Antibody

     
  • WB - CBLN1 / Cerebellin 1 Antibody ALS11409
    Western blot of precerebellin in mouse cerebellum lysate with ALS11409 at (A) 2 and (B) 4 ug/ml.
  • IHC - CBLN1 / Cerebellin 1 Antibody ALS11409
    Anti-CBLN1 / Precerebellin antibody IHC of mouse small intestine.
  • IHC - CBLN1 / Cerebellin 1 Antibody ALS11409
    Anti-CBLN1 / Precerebellin antibody IHC of mouse kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P23435
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 21kDa
Dilution IHC-P (10 µg/ml), WB (2-4 µg/ml),
Additional Information
Gene ID 869
Other Names Cerebellin-1, Precerebellin, Cerebellin, CER, [des-Ser1]-cerebellin, CBLN1
Target/Specificity 15 amino acid peptide from the middle of human precerebellin
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCBLN1 / Cerebellin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBLN1
Function Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity).
Cellular Location Secreted. Cell junction, synapse, postsynaptic cell membrane
Tissue Location In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des- Ser1]-cerebellin
Research Areas
Citations (0)

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Background

Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity).

References

Urade Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1069-1073(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Yiangou Y.,et al.J. Neurochem. 53:886-889(1989).

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$ 395.00
Cat# ALS11409
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