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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   NLRP2 / NALP2 Antibody (C-Terminus)   

NLRP2 / NALP2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - NLRP2 / NALP2 Antibody (C-Terminus) ALS11420
    Western blot of NALP2 in PC-3 cell lysate with NALP2 antibody at (A) 1 and (B) 2 ug/ml.
  • IHC - NLRP2 / NALP2 Antibody (C-Terminus) ALS11420
    Anti-NALP2 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9NX02
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 121kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 55655
Other Names NACHT, LRR and PYD domains-containing protein 2, Nucleotide-binding site protein 1, PYRIN domain and NACHT domain-containing protein 1, PYRIN-containing APAF1-like protein 2, NLRP2, NALP2, NBS1, PAN1, PYPAF2
Target/Specificity peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsNLRP2 / NALP2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP2
Synonyms NALP2, NBS1, PAN1, PYPAF2
Function Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Cellular Location Cytoplasm
Tissue Location Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain
Research Areas
Citations (0)

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Background

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

References

Bertin J.,et al.Cell Death Differ. 7:1273-1274(2000).
Martinon F.,et al.Curr. Biol. 11:R118-R120(2001).
Wang L.,et al.J. Biol. Chem. 277:29874-29880(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11420
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