|Application ||WB, IHC-P|
|Dilution||IHC-P (5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Protein BEX3, Brain-expressed X-linked protein 3, Nerve growth factor receptor-associated protein 1, Ovarian granulosa cell 13.0 kDa protein HGR74, p75NTR-associated cell death executor, NGFRAP1, BEX3, DXS6984E, NADE|
|Target/Specificity||peptide corresponding to 14 amino acids near the middle of human NADE|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||NGFRAP1 / NADE / Bex Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity).|
|Tissue Location||Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.|
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Provided below are standard protocols that you may find useful for product applications.
May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
Rapp G.,et al.DNA Cell Biol. 9:479-485(1990).
Mukai J.,et al.J. Biol. Chem. 275:17566-17570(2000).
Alvarez E.,et al.Gene 357:18-28(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zhou X.,et al.Mol. Vis. 13:2214-2221(2007).
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