RPAIN Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q86UA6 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 25kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 84268 |
---|---|
Other Names | RPA-interacting protein, hRIP, RPAIN, RIP |
Target/Specificity | 17 amino acid peptide from near the carboxy terminus of human RPA IP. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | RPAIN Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RPAIN |
---|---|
Synonyms | RIP |
Function | Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. |
Cellular Location | [Isoform 1]: Cytoplasm. Nucleus. |
Tissue Location | Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
References
Chen J.-Z.,et al.DNA Cell Biol. 24:464-469(2005).
Park J.,et al.Mol. Cell. Biol. 25:8202-8214(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
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