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RRM2B Antibody (aa2-17)

Rabbit Polyclonal Antibody

     
  • IF - RRM2B Antibody (aa2-17) ALS11436
    Immunofluorescence of p53R2 in Human Lung cells with p53R2 antibody at 20 ug/ml.
  • IHC - RRM2B Antibody (aa2-17) ALS11436
    Anti-RRM2B / p53R2 antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q7LG56
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Dilution IHC-P (2.5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 50484
Other Names Ribonucleoside-diphosphate reductase subunit M2 B, 1.17.4.1, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2, RRM2B, P53R2
Target/Specificity synthetic peptide (GDPERPEAAGLDQDER) corresponding to amino acids 2 to 17 of human p53R2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsRRM2B Antibody (aa2-17) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RRM2B
Synonyms P53R2
Function Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Cellular Location Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage
Tissue Location Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma
Research Areas
Citations (0)

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Background

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.

References

Tanaka H.,et al.Nature 404:42-49(2000).
Ugai H.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nusbaum C.,et al.Nature 439:331-335(2006).

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$ 395.00
Cat# ALS11436
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