|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog|
|Dilution||IHC-P (2.5 µg/ml), WB (0.5-1 µg/ml),|
|Other Names||RING1 and YY1-binding protein, Apoptin-associating protein 1, APAP-1, Death effector domain-associated factor, DED-associated factor, YY1 and E4TF1-associated factor 1, RYBP, DEDAF, YEAF1|
|Target/Specificity||synthetic peptide (TPKGDMSAVNDESF) corresponding to amino acids 215 to 228 of human DEDAF The sequence is identical to that of mouse origin|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||RYBP Antibody (aa215-228) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.|
|Cellular Location||Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity).|
|Tissue Location||Widely expressed with highest levels in lymphoid tissues and placenta.|
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Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.
Zheng L.,et al.J. Biol. Chem. 276:31945-31952(2001).
Sawa C.,et al.J. Biol. Chem. 277:22484-22490(2002).
Danen-van Oorschot A.A.M.M.,et al.Cell Death Differ. 11:564-573(2004).
Cheng C.M.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Gearhart M.D.,et al.Mol. Cell. Biol. 26:6880-6889(2006).
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