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DAPK2 / DAP Kinase 2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - DAPK2 / DAP Kinase 2 Antibody (C-Terminus) ALS11447
    Western blot of DAPK2 in A431 (H), mouse spleen (M), and rat kidney (R) lysates with DAPK2...
    detail
  • IHC - DAPK2 / DAP Kinase 2 Antibody (C-Terminus) ALS11447
    Anti-DAPK2 antibody IHC of human breast.
    detail
  • IHC - DAPK2 / DAP Kinase 2 Antibody (C-Terminus) ALS11447
    Anti-DAPK2 antibody IHC of human prostate.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9UIK4
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 23604
Other Names Death-associated protein kinase 2, DAP kinase 2, 2.7.11.1, DAP-kinase-related protein 1, DRP-1, DAPK2
Target/Specificity peptide corresponding to amino acids near the carboxy terminus of human DAPK2 The sequence of this antigenic peptide is identical to the corresponding amino acids of mouse origin (1,2)
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsDAPK2 / DAP Kinase 2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DAPK2
Function Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).
Cellular Location Cytoplasm. Cytoplasmic vesicle, autophagosome lumen
Tissue Location Expressed in neutrophils and eosinophils (PubMed:24163421). Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle
Research Areas
Citations (0)
citation

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Background

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation.

References

Kawai T.,et al.Oncogene 18:3471-3480(1999).
Inbal B.,et al.Mol. Cell. Biol. 20:1044-1054(2000).
Shoval Y.,et al.PLoS ONE 6:E17344-E17344(2011).
Zody M.C.,et al.Nature 440:671-675(2006).
Shani G.,et al.EMBO J. 20:1099-1113(2001).

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Discontinued
Cat# ALS11447
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