|Application ||WB, IHC-P, ICC|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||DNA fragmentation factor subunit beta, 3.-.-.-, Caspase-activated deoxyribonuclease, CAD, Caspase-activated DNase, Caspase-activated nuclease, CPAN, DNA fragmentation factor 40 kDa subunit, DFF-40, DFFB, CAD, DFF2, DFF40|
|Target/Specificity||peptide corresponding to amino acids near the center of murine CAD The sequence differs from human DFF40 by two amino acids (3,4)|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||DFFB Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAD, DFF2, DFF40|
|Function||Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.|
|Cellular Location||Cytoplasm. Nucleus.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Liu X.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:8461-8466(1998).
Mukae N.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:9123-9128(1998).
Halenbeck R.,et al.Curr. Biol. 8:537-540(1998).
Nakagawara A.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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