|Application ||WB, IHC-P|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||Deoxyribonuclease-2-alpha, 126.96.36.199, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II, R31240_2, DNASE2, DNASE2A, DNL2|
|Target/Specificity||peptide corresponding to amino acids 347 to 360 of human DNase II precursor (2-4)|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||DNASE2 / DNase II Antibody (aa347-360) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
Yasuda T.,et al.Ann. Hum. Genet. 62:299-305(1998).
Shiokawa D.,et al.Biochem. Biophys. Res. Commun. 247:864-869(1998).
Baker K.P.,et al.Gene 215:281-289(1998).
Krieser R.J.,et al.J. Biol. Chem. 273:30909-30914(1998).
Yasuda T.,et al.J. Biol. Chem. 273:2610-2616(1998).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.