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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   DNASE2 / DNase II Antibody (aa347-360)   

DNASE2 / DNase II Antibody (aa347-360)

Rabbit Polyclonal Antibody

     
  • WB - DNASE2 / DNase II Antibody (aa347-360) ALS11451
    Western blot of DNase II in human spleen tissue lysate in the absence (lane 1) or presence (lane...
  • IHC - DNASE2 / DNase II Antibody (aa347-360) ALS11451
    Anti-DNASE2 / DNase II antibody IHC of human thymus.
  • IHC - DNASE2 / DNase II Antibody (aa347-360) ALS11451
    Anti-DNASE2 / DNase II antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O00115
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 40kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 1777
Other Names Deoxyribonuclease-2-alpha, 3.1.22.1, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II, R31240_2, DNASE2, DNASE2A, DNL2
Target/Specificity peptide corresponding to amino acids 347 to 360 of human DNase II precursor (2-4)
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsDNASE2 / DNase II Antibody (aa347-360) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNASE2
Synonyms DNASE2A, DNL2
Function Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
Cellular Location Lysosome.
Research Areas
Citations (0)

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Background

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

References

Yasuda T.,et al.Ann. Hum. Genet. 62:299-305(1998).
Shiokawa D.,et al.Biochem. Biophys. Res. Commun. 247:864-869(1998).
Baker K.P.,et al.Gene 215:281-289(1998).
Krieser R.J.,et al.J. Biol. Chem. 273:30909-30914(1998).
Yasuda T.,et al.J. Biol. Chem. 273:2610-2616(1998).

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$ 395.00
Cat# ALS11451
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