|Application ||WB, IHC-P|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||Deoxyribonuclease-2-alpha, 18.104.22.168, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II, R31240_2, DNASE2, DNASE2A, DNL2|
|Target/Specificity||peptide corresponding to amino acids 347 to 360 of human DNase II precursor (2-4)|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||DNASE2 / DNase II Antibody (aa347-360) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.|
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Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
Yasuda T.,et al.Ann. Hum. Genet. 62:299-305(1998).
Shiokawa D.,et al.Biochem. Biophys. Res. Commun. 247:864-869(1998).
Baker K.P.,et al.Gene 215:281-289(1998).
Krieser R.J.,et al.J. Biol. Chem. 273:30909-30914(1998).
Yasuda T.,et al.J. Biol. Chem. 273:2610-2616(1998).
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