|Application ||WB, IHC-P, IF, ICC|
|Dilution||IHC-P (5 µg/ml), WB (0.5-1 µg/ml),|
|Other Names||Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62, DOK1|
|Target/Specificity||peptide corresponding to amino acids near the carboxy terminus of human p62dok|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||DOK1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.|
|Cellular Location||Isoform 1: Cytoplasm. Nucleus.|
|Tissue Location||Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer|
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Provided below are standard protocols that you may find useful for product applications.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Carpino N.,et al.Cell 88:197-204(1997).
Hubert P.,et al.Eur. J. Immunogenet. 27:145-148(2000).
Yu W.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Wick M.J.,et al.J. Biol. Chem. 276:42843-42850(2001).
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