|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Interleukin-31, IL-31, IL31|
|Target/Specificity||18 amino acid peptide from near the center of human IL-31|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||IL31 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).|
|Tissue Location||Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.|
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Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.
Dillon S.R.,et al.Nat. Immunol. 5:752-760(2004).
Bilsborough J.,et al.J. Allergy Clin. Immunol. 117:418-425(2006).
Neis M.M.,et al.J. Allergy Clin. Immunol. 118:930-937(2006).
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