|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Interleukin-31, IL-31, IL31|
|Target/Specificity||18 amino acid peptide from near the center of human IL-31|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||IL31 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).|
|Tissue Location||Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.|
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Provided below are standard protocols that you may find useful for product applications.
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.
Dillon S.R.,et al.Nat. Immunol. 5:752-760(2004).
Bilsborough J.,et al.J. Allergy Clin. Immunol. 117:418-425(2006).
Neis M.M.,et al.J. Allergy Clin. Immunol. 118:930-937(2006).
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