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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   ICSBP / IRF8 Antibody (C-Terminus)   

ICSBP / IRF8 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - ICSBP / IRF8 Antibody (C-Terminus) ALS11468
    Immunofluorescence of IRF8 in K562 cells with IRF8 antibody at 10 ug/ml.
  • WB - ICSBP / IRF8 Antibody (C-Terminus) ALS11468
    Western blot of IRF8 in human thymus tissue lysate with IRF8 antibody at 1ug/ml in (A) the...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q02556
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 3394
Other Names Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, H-ICSBP, ICSBP, IRF8, ICSBP1
Target/Specificity peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsICSBP / IRF8 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRF8
Synonyms ICSBP1
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).
Cellular Location Nucleus.
Tissue Location Predominantly expressed in lymphoid tissues.
Research Areas
Citations (0)

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Background

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).

References

Weisz A.,et al.J. Biol. Chem. 267:25589-25596(1992).
Schmidt M.,et al.Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
Cohen H.,et al.J. Biol. Chem. 275:39081-39089(2000).
Basso K.,et al.J. Exp. Med. 209:2455-2465(2012).
Sjoeblom T.,et al.Science 314:268-274(2006).

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$ 395.00
Cat# ALS11468
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