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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DENN / MADD Antibody (C-Terminus)   

DENN / MADD Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - DENN / MADD Antibody (C-Terminus) ALS11473
    Immunocytochemistry of MADD in human spleen tissue with MADD antibody at 10 ug/ml.
  • IF - DENN / MADD Antibody (C-Terminus) ALS11473
    Immunofluorescence of MADD in HeLa cells with MADD antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q8WXG6
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 183kDa
Dilution IHC-P (2.5 µg/ml), WB (1:250-1:500),
Additional Information
Gene ID 8567
Other Names MAP kinase-activating death domain protein, Differentially expressed in normal and neoplastic cells, Insulinoma glucagonoma clone 20, Rab3 GDP/GTP exchange factor, MADD {ECO:0000312|EMBL:AAB57735.1, ECO:0000312|HGNC:HGNC:6766}
Target/Specificity peptide corresponding to amino acids near the carboxy terminus of human MADD
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsDENN / MADD Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MADD {ECO:0000312|EMBL:AAB57735.1, ECO:0000312|HGNC:HGNC:6766}
Function Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
Cellular Location Membrane. Cytoplasm
Tissue Location Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines.
Research Areas
Citations (0)

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Background

Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.

References

Chow V.T.K.,et al.DNA Seq. 6:263-273(1996).
Schievella A.R.,et al.J. Biol. Chem. 272:12069-12075(1997).
Chow V.T.K.,et al.Genome 41:543-552(1998).
Al-Zoubi A.M.,et al.J. Biol. Chem. 276:47202-47211(2001).
Nagase T.,et al.DNA Res. 4:141-150(1997).

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$ 395.00
Cat# ALS11473
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