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MCL1 / MCL 1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - MCL1 / MCL 1 Antibody (C-Terminus) ALS11476
    Immunocytochemistry staining of Raji cells using Mcl-1 antibody at 2 ug/ml.
    detail
  • IF - MCL1 / MCL 1 Antibody (C-Terminus) ALS11476
    Immunofluorescence of Mcl-1 in Raji cells with Mcl-1 antibody at 10 ug/ml.
    detail
  • IHC - MCL1 / MCL 1 Antibody (C-Terminus) ALS11476
    Anti-MCL1 antibody IHC of human brain, cortex.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q07820
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 37kDa
Dilution IHC-P (2.5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 4170
Other Names Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3
Target/Specificity peptide corresponding to 16 amino acids near the carboxy-terminus of human Mcl-1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsMCL1 / MCL 1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCL1
Synonyms BCL2L3
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Cellular Location Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm Note=Cytoplasmic, associated with mitochondria
Research Areas
Citations (0)
citation

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Background

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

References

Kozopas K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3516-3520(1993).
Umezawa A.,et al.Cell Struct. Funct. 21:143-150(1996).
Akgul C.,et al.Cell. Mol. Life Sci. 57:684-691(2000).
Bingle C.D.,et al.J. Biol. Chem. 275:22136-22146(2000).
Bae J.,et al.J. Biol. Chem. 275:25255-25261(2000).

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Discontinued
Cat# ALS11476
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