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MTA2 Antibody (aa52-8)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | O94776 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75kDa |
| Dilution | IHC-P (2.5 µg/ml), WB (0.5-1 µg/ml), |
| Gene ID | 9219 |
|---|---|
| Other Names | Metastasis-associated protein MTA2, Metastasis-associated 1-like 1, MTA1-L1 protein, p53 target protein in deacetylase complex, MTA2, MTA1L1, PID |
| Target/Specificity | Raised against a synthetic peptide corresponding to amino acids 652 to 668 of human PID, which differ from the mouse sequence by one amino acid. No cross response to MTA1. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | MTA2 Antibody (aa52-8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTA2 |
|---|---|
| Synonyms | MTA1L1, PID |
| Function | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408} |
| Tissue Location | Widely expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
References
Futamura M.,et al.J. Hum. Genet. 44:52-56(1999).
Luo J.,et al.Nature 408:377-381(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Taylor T.D.,et al.Nature 440:497-500(2006).
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